Adenosine and a nitric oxide donor enhances cardioprotection by preconditioning with isoflurane through mitochondrial adenosine triphosphate-sensitive K+ channel-dependent and -independent mechanisms.

Wakeno-Takahashi, Mayu; Otani, Hajime; Nakao, Shinichi; Uchiyama, Yuka; Imamura, Hiroji; Shingu, Koh

Wakeno-Takahashi, Mayu; Otani, Hajime; Nakao, Shinichi; Uchiyama, Yuka; Imamura, Hiroji; Shingu, Koh.

Affiliation

Wakeno-Takahashi M; Department of Anesthesiology, Kansai Medical University, Moriguchi City, Japan.

Anesthesiology ; 100(3): 515-24, 2004 Mar.

Article in En | MEDLINE | ID: mdl-15108963

Subject(s)

Adenosine/pharmacology; Anesthetics, Inhalation/pharmacology; Cardiovascular Agents/pharmacology; Ischemic Preconditioning, Myocardial/methods; Isoflurane/pharmacology; Membrane Proteins/physiology; Mitochondria, Heart/metabolism; Nitric Oxide Donors/pharmacology; Animals; Diazoxide/pharmacology; Dose-Response Relationship, Drug; Flavoproteins/metabolism; In Vitro Techniques; Male; Membrane Proteins/drug effects; Mitochondria, Heart/drug effects; Myocardial Infarction/pathology; Myocardial Infarction/prevention & control; Oxidation-Reduction; Potassium Channels; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Agents / Adenosine / Anesthetics, Inhalation / Ischemic Preconditioning, Myocardial / Nitric Oxide Donors / Isoflurane / Membrane Proteins / Mitochondria, Heart Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Anesthesiology Year: 2004 Document type: Article Affiliation country: Japan Country of publication: United States

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