Evidence that morphine tolerance may be regulated by endothelin in the neonatal rat.

Puppala, Bhagya L; Matwyshyn, George; Bhalla, Shaifali; Gulati, Anil

Puppala, Bhagya L; Matwyshyn, George; Bhalla, Shaifali; Gulati, Anil.

Affiliation

Puppala BL; Department of Pediatrics and Neonatology, Advocate Lutheran General Children's Hospital, Park Ridge, IL, USA.

Biol Neonate ; 86(2): 138-44, 2004.

Article in En | MEDLINE | ID: mdl-15218283

Subject(s)

Animals, Newborn; Drug Tolerance; Endothelins/physiology; Morphine; Animals; Brain/metabolism; Brain Chemistry; Dansyl Compounds/pharmacology; Endothelin A Receptor Antagonists; Endothelin-1/metabolism; Endothelin-1/pharmacology; Endothelins/pharmacology; Female; GTP-Binding Proteins/physiology; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism; Morphine/pharmacology; Peptide Fragments/pharmacology; Placebos; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A/physiology; Receptor, Endothelin B/agonists; Receptor, Endothelin B/physiology; Receptors, Endothelin/analysis; Receptors, Endothelin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelins / Drug Tolerance / Animals, Newborn / Morphine Limits: Animals / Pregnancy Language: En Journal: Biol Neonate Year: 2004 Document type: Article Affiliation country: United States

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