Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice.

Kee, Kristin; Foster, Barbara A; Merali, Salim; Kramer, Debora L; Hensen, Mary L; Diegelman, Paula; Kisiel, Nicholas; Vujcic, Slavoljub; Mazurchuk, Richard V; Porter, Carl W

Kee, Kristin; Foster, Barbara A; Merali, Salim; Kramer, Debora L; Hensen, Mary L; Diegelman, Paula; Kisiel, Nicholas; Vujcic, Slavoljub; Mazurchuk, Richard V; Porter, Carl W.

Affiliation

Kee K; Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

J Biol Chem ; 279(38): 40076-83, 2004 Sep 17.

Article in En | MEDLINE | ID: mdl-15252047

Subject(s)

Acetyl Coenzyme A/metabolism; Acetyltransferases/genetics; Adenocarcinoma/metabolism; Polyamines/metabolism; Prostatic Neoplasms/metabolism; Acetyltransferases/metabolism; Adenocarcinoma/pathology; Adenocarcinoma/physiopathology; Androgen-Binding Protein/genetics; Animals; Antigens, Polyomavirus Transforming/genetics; Disease Models, Animal; Female; Genetic Predisposition to Disease; Male; Mice; Mice, Transgenic; Prostate/pathology; Prostate/physiopathology; Prostatic Neoplasms/pathology; Prostatic Neoplasms/physiopathology; Rats

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Collection: 01-internacional Database: MEDLINE Main subject: Acetyl Coenzyme A / Polyamines / Prostatic Neoplasms / Acetyltransferases / Adenocarcinoma Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States

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