Evaluation of the therapeutic potential of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib in preclinical models of bladder cancer.

Dominguez-Escrig, Jose L; Kelly, John D; Neal, David E; King, Sonya M; Davies, Barry R

Dominguez-Escrig, Jose L; Kelly, John D; Neal, David E; King, Sonya M; Davies, Barry R.

Affiliation

Dominguez-Escrig JL; Northern Institute for Cancer Research, School of Surgical and Reproductive Sciences, Faculty of Medical Sciences, University of Newcastle, Newcastle-Upon-Tyne, United Kingdom.

Clin Cancer Res ; 10(14): 4874-84, 2004 Jul 15.

Article in En | MEDLINE | ID: mdl-15269164

Subject(s)

ErbB Receptors/antagonists & inhibitors; Protein Kinase Inhibitors/pharmacology; Quinazolines/pharmacology; Urinary Bladder Neoplasms/prevention & control; Animals; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Proliferation/radiation effects; Cell Survival/drug effects; Cell Survival/radiation effects; DNA/biosynthesis; Dose-Response Relationship, Drug; ErbB Receptors/metabolism; Gefitinib; Humans; Male; Mice; Mice, Nude; Mitogen-Activated Protein Kinases/metabolism; Phosphorylation/drug effects; Protein Kinase Inhibitors/therapeutic use; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Quinazolines/therapeutic use; Urinary Bladder Neoplasms/metabolism; Urinary Bladder Neoplasms/pathology; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Urinary Bladder Neoplasms / Protein Kinase Inhibitors / ErbB Receptors Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2004 Document type: Article Affiliation country: United kingdom Country of publication: United States

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