Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models.

Tréhin, Rachel; Krauss, Ulrike; Beck-Sickinger, Annette G; Merkle, Hans P; Nielsen, Hanne M

Tréhin, Rachel; Krauss, Ulrike; Beck-Sickinger, Annette G; Merkle, Hans P; Nielsen, Hanne M.

Affiliation

Tréhin R; Department of Chemistry and Applied BioSciences, Swiss Federal Institute of Technology Zurich (ETH Zurich), Zurich, Switzerland.

Pharm Res ; 21(7): 1248-56, 2004 Jul.

Article in En | MEDLINE | ID: mdl-15290867

Subject(s)

Calcitonin/chemistry; Epithelial Cells/metabolism; Gene Products, tat/chemistry; Peptide Fragments/pharmacokinetics; Animals; Carrier Proteins/chemistry; Cell Line; Cell Membrane Permeability; Cell-Penetrating Peptides; Chromatography, High Pressure Liquid; Epithelial Cells/drug effects; Fluoresceins/chemistry; Fluorescent Dyes/chemistry; Humans; Microscopy, Confocal; Peptide Fragments/chemistry; Peptide Fragments/toxicity

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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Calcitonin / Gene Products, tat / Epithelial Cells Limits: Animals / Humans Language: En Journal: Pharm Res Year: 2004 Document type: Article Affiliation country: Switzerland Country of publication: United States

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