Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.

Labrie, Joseph E; Sah, Alex P; Allman, David M; Cancro, Michael P; Gerstein, Rachel M

Labrie, Joseph E; Sah, Alex P; Allman, David M; Cancro, Michael P; Gerstein, Rachel M.

Affiliation

Labrie JE; Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave. N., Worcester 01655, USA.

J Exp Med ; 200(4): 411-23, 2004 Aug 16.

Article in En | MEDLINE | ID: mdl-15314072

Subject(s)

Aging/immunology; B-Lymphocytes/immunology; Bone Marrow/immunology; DNA-Binding Proteins/metabolism; Immunity, Cellular/immunology; VDJ Recombinases/metabolism; Animals; Bromodeoxyuridine; Flow Cytometry; Gene Expression Regulation; Mice; Mice, Inbred Strains; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow / Aging / B-Lymphocytes / VDJ Recombinases / DNA-Binding Proteins / Immunity, Cellular Limits: Animals Language: En Journal: J Exp Med Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States

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