A noncompetitive, sequential mechanism for inhibition of rat alpha4beta2 neuronal nicotinic acetylcholine receptors by carbamate pesticides.

Smulders, Chantal J G M; Van Kleef, Regina G D M; de Groot, Aart; Gotti, Cecilia; Vijverberg, Henk P M

Smulders, Chantal J G M; Van Kleef, Regina G D M; de Groot, Aart; Gotti, Cecilia; Vijverberg, Henk P M.

Affiliation

Smulders CJ; Institute for Risk Assessment Sciences, Utrecht University, NL-3508 TD Utrecht, The Netherlands.

Toxicol Sci ; 82(1): 219-27, 2004 Nov.

Article in En | MEDLINE | ID: mdl-15329441

Subject(s)

Carbamates; Nicotinic Antagonists/toxicity; Pesticides/toxicity; Receptors, Nicotinic/drug effects; Xenopus laevis; Animals; Bridged Bicyclo Compounds, Heterocyclic/pharmacokinetics; Dose-Response Relationship, Drug; Electrophysiology; Female; Inhibitory Concentration 50; Oocytes/drug effects; Oocytes/metabolism; Patch-Clamp Techniques; Pyridines/pharmacokinetics; Rats; Receptors, Nicotinic/metabolism; Time Factors; Tritium

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Collection: 01-internacional Database: MEDLINE Main subject: Pesticides / Xenopus laevis / Carbamates / Receptors, Nicotinic / Nicotinic Antagonists Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2004 Document type: Article Affiliation country: Netherlands

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