Detection by 32P-postlabelling of 8-oxo-7,8-dihydro-2'-deoxyguanosine in DNA as biomarker of microcystin-LR- and nodularin-induced DNA damage in vitro in primary cultured rat hepatocytes and in vivo in rat liver.

Maatouk, Imed; Bouaïcha, Noureddine; Plessis, Marie José; Périn, François

Maatouk, Imed; Bouaïcha, Noureddine; Plessis, Marie José; Périn, François.

Affiliation

Maatouk I; Laboratoire Raymond Latarjet, Institut Curie-Section Recherche, Bâtiment 112, Centre Universitaire, 91405 Orsay Cedex, France.

Mutat Res ; 564(1): 9-20, 2004 Nov 14.

Article in En | MEDLINE | ID: mdl-15474406

Subject(s)

DNA Damage; DNA/drug effects; Deoxyguanosine/analogs & derivatives; Deoxyguanosine/metabolism; Hepatocytes/drug effects; Liver/drug effects; Peptides, Cyclic/toxicity; 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Cells, Cultured; DNA/chemistry; Enzyme Inhibitors/toxicity; Hepatocytes/cytology; Hepatocytes/metabolism; Humans; Liver/physiology; Male; Marine Toxins; Microcystins; Phosphorus Radioisotopes/metabolism; Rats; Rats, Sprague-Dawley

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / DNA Damage / DNA / Hepatocytes / Deoxyguanosine / Liver Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Mutat Res Year: 2004 Document type: Article Affiliation country: France Country of publication: Netherlands

Search on Google

Add to My VHL

XML

PubMed Links