Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation.

Gerasimovskaya, Evgenia V; Tucker, Doug A; Stenmark, Kurt R

Gerasimovskaya, Evgenia V; Tucker, Doug A; Stenmark, Kurt R.

Affiliation

Gerasimovskaya EV; Developmental Lung Biology Laboratory, Univ. of Colorado Health Sciences Center, 4200 E. 9th Ave., Box B131, Denver, CO 80262, USA.

J Appl Physiol (1985) ; 98(2): 722-31, 2005 Feb.

Article in En | MEDLINE | ID: mdl-15501927

Subject(s)

Cell Hypoxia/physiology; Fibroblasts/physiology; Phosphatidylinositol 3-Kinases/metabolism; Protein Kinases/metabolism; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Pulmonary Artery/growth & development; Pulmonary Artery/metabolism; Animals; Cattle; Cell Proliferation; Cells, Cultured; Enzyme Activation; Fibroblasts/cytology; Proto-Oncogene Proteins c-akt; Pulmonary Artery/cytology; Pulmonary Artery/embryology; Signal Transduction/physiology; TOR Serine-Threonine Kinases

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Pulmonary Artery / Cell Hypoxia / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Phosphatidylinositol 3-Kinases / Fibroblasts Limits: Animals Language: En Journal: J Appl Physiol (1985) Journal subject: FISIOLOGIA Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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