Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux.

Wong, Jenny; Quinn, Carmel M; Brown, Andrew J

Wong, Jenny; Quinn, Carmel M; Brown, Andrew J.

Affiliation

Wong J; School of Biotechnology and Biomolecular Sciences, The University of New South Wales and Centre for Vascular Research, Sydney, Australia.

Arterioscler Thromb Vasc Biol ; 24(12): 2365-71, 2004 Dec.

Article in En | MEDLINE | ID: mdl-15514210

Subject(s)

ATP-Binding Cassette Transporters/genetics; Cholesterol/analogs & derivatives; Cholesterol/biosynthesis; Cholesterol/metabolism; DNA-Binding Proteins/metabolism; Hydroxymethylglutaryl-CoA Reductase Inhibitors/metabolism; Lovastatin/analogs & derivatives; Macrophages/chemistry; Macrophages/metabolism; Receptors, Cytoplasmic and Nuclear/metabolism; Tetradecanoylphorbol Acetate/analogs & derivatives; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; Cell Differentiation/physiology; Cell Line; Cholesterol/pharmacology; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Humans; Ligands; Liver X Receptors; Lovastatin/pharmacology; Macrophages/drug effects; Macrophages/physiology; Monocytes/physiology; Orphan Nuclear Receptors; Tetradecanoylphorbol Acetate/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Tetradecanoylphorbol Acetate / Lovastatin / Cholesterol / Receptors, Cytoplasmic and Nuclear / ATP-Binding Cassette Transporters / Hydroxymethylglutaryl-CoA Reductase Inhibitors / DNA-Binding Proteins / Macrophages Limits: Humans Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2004 Document type: Article Affiliation country: Australia

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