Tumor necrosis factor-alpha (TNF-alpha) promotes cell survival during spermatogenesis, and this effect can be blocked by infliximab, a TNF-alpha antagonist.

Suominen, Janne S; Wang, Yangyang; Kaipia, Antti; Toppari, Jorma

Suominen, Janne S; Wang, Yangyang; Kaipia, Antti; Toppari, Jorma.

Affiliation

Suominen JS; Departments of Physiology and Pediatrics, University of Turku, Turku, Finland.

Eur J Endocrinol ; 151(5): 629-40, 2004 Nov.

Article in En | MEDLINE | ID: mdl-15538942

Subject(s)

Antibodies, Monoclonal/pharmacology; Seminiferous Tubules/physiology; Spermatogenesis/physiology; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Tumor Necrosis Factor-alpha/pharmacology; Active Transport, Cell Nucleus/drug effects; Animals; Apoptosis; Cell Survival/drug effects; Dose-Response Relationship, Drug; Infliximab; Male; Mitochondria/metabolism; NF-kappa B/antagonists & inhibitors; NF-kappa B/metabolism; Peptides/pharmacology; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; Rats, Sprague-Dawley; Seminiferous Tubules/cytology; Tumor Necrosis Factor-alpha/administration & dosage; bcl-X Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Seminiferous Tubules / Spermatogenesis / Tumor Necrosis Factor-alpha / Antibodies, Monoclonal Limits: Animals Language: En Journal: Eur J Endocrinol Journal subject: ENDOCRINOLOGIA Year: 2004 Document type: Article Affiliation country: Finland Country of publication: United kingdom

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