Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas.

Tsuji, Hideo; Ishii-Ohba, Hiroko; Katsube, Takanori; Ukai, Hideki; Aizawa, Shiro; Doi, Masahiro; Hioki, Kyoji; Ogiu, Toshiaki

Tsuji, Hideo; Ishii-Ohba, Hiroko; Katsube, Takanori; Ukai, Hideki; Aizawa, Shiro; Doi, Masahiro; Hioki, Kyoji; Ogiu, Toshiaki.

Affiliation

Tsuji H; Low Dose Radiation Effects Research Project Group, Radiation Hazards Research Group, and Environmental and Toxicological Science Research Group, National Institute of Radiological Sciences, Chiba, Japan. tsujihid@nirs.go.jp

Cancer Res ; 64(24): 8882-90, 2004 Dec 15.

Article in En | MEDLINE | ID: mdl-15604248

Subject(s)

Lymphoma/genetics; Neoplasms, Radiation-Induced/genetics; Receptors, Cell Surface/genetics; Thymus Neoplasms/genetics; Transcription Factors/genetics; Animals; Base Sequence; Cell Line, Tumor; Chromosome Breakage; DNA-Activated Protein Kinase; DNA-Binding Proteins/deficiency; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Gene Deletion; Gene Rearrangement; Lymphoma/etiology; Mice; Mice, Inbred BALB C; Mice, SCID; Neoplasms, Radiation-Induced/etiology; Protein Serine-Threonine Kinases/deficiency; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Receptor, Notch1; Recombination, Genetic/genetics; Signal Transduction; Thymus Gland/radiation effects; Thymus Neoplasms/etiology; VDJ Recombinases; X-Rays

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Collection: 01-internacional Database: MEDLINE Main subject: Thymus Neoplasms / Transcription Factors / Receptors, Cell Surface / Lymphoma / Neoplasms, Radiation-Induced Type of study: Etiology_studies Limits: Animals Language: En Journal: Cancer Res Year: 2004 Document type: Article Affiliation country: Japan Country of publication: United States

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