[Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats].

Tian, Jian-ming; Li, Hao; Ye, Jin-mei; Guo, Wei-fang; Li, Lon-yun; Wang, Li-ping

Tian, Jian-ming; Li, Hao; Ye, Jin-mei; Guo, Wei-fang; Li, Lon-yun; Wang, Li-ping.

Affiliation

Tian JM; Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun 130021, Jilin, China.

Zhongguo Zhong Yao Za Zhi ; 28(12): 1191-2, 2003 Dec.

Article in Zh | MEDLINE | ID: mdl-15617510

ABSTRACT

OBJECTIVE: To investigate the protective effect of Ginsenoside Rg2 on Chemical myocardial ischemia. METHOD: The models of myocardial ischemia were built in rats with isoproterenol, sodium nitrite,pituitrin. Ginsenoside Rg2 (iv 2.5, 5.0, 10.0 mg x kg(-1)) were intravenously administered. RESULT: Ginsenoside Rg2 could improve the abnormal electrocardiogram (ECG), reduce the arca of myocardial ischemia and improve the abnormal zymologic value of myocardial. CONCLUSION: Ginsenoside Rg2 has inhibitory function on myocardialischemia.

Subject(s)

Ginsenosides/pharmacology; Myocardial Ischemia; Myocardium/pathology; Superoxide Dismutase/metabolism; Animals; Creatine Kinase/metabolism; Electrocardiography/drug effects; Female; Ginsenosides/isolation & purification; Isoproterenol; Male; Malondialdehyde/metabolism; Myocardial Ischemia/chemically induced; Myocardial Ischemia/pathology; Myocardial Ischemia/physiopathology; Panax/chemistry; Pituitary Hormones, Posterior; Plant Leaves/chemistry; Plants, Medicinal/chemistry; Rats; Rats, Wistar; Sodium Nitrite

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Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Myocardial Ischemia / Ginsenosides / Myocardium Limits: Animals Language: Zh Journal: Zhongguo Zhong Yao Za Zhi Journal subject: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Year: 2003 Document type: Article Affiliation country: China Country of publication: China

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