Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations.

Fioriti, Luana; Dossena, Sara; Stewart, Leanne R; Stewart, Richard S; Harris, David A; Forloni, Gianluigi; Chiesa, Roberto

Fioriti, Luana; Dossena, Sara; Stewart, Leanne R; Stewart, Richard S; Harris, David A; Forloni, Gianluigi; Chiesa, Roberto.

Affiliation

Fioriti L; Dulbecco Telethon Institute (DTI) and Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano 20157, Italy.

J Biol Chem ; 280(12): 11320-8, 2005 Mar 25.

Article in En | MEDLINE | ID: mdl-15632159

Subject(s)

Cysteine Proteinase Inhibitors/toxicity; Cytosol/metabolism; Mutation; Prion Diseases/etiology; Prions/metabolism; Proteasome Endopeptidase Complex/physiology; Animals; Cells, Cultured; Cerebellum/metabolism; Leupeptins/toxicity; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Prions/genetics; Prions/toxicity; Proteasome Inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Prions / Cysteine Proteinase Inhibitors / Prion Diseases / Cytosol / Proteasome Endopeptidase Complex / Mutation Limits: Animals Language: En Journal: J Biol Chem Year: 2005 Document type: Article Affiliation country: Italy Country of publication: United States

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