Gene Expression Regulation/physiology; Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism; Inclusion Bodies/metabolism; Lewy Bodies/metabolism; Acetates/metabolism; Aged; Aged, 80 and over; Animals; Blotting, Western/methods; Brain/metabolism; COS Cells; Cell Aggregation/physiology; Cell Count; Chlorocebus aethiops; Female; Green Fluorescent Proteins/metabolism; Humans; Immunohistochemistry/methods; Immunoprecipitation/methods; Inclusion Bodies/ultrastructure; Indoles; Lewy Bodies/ultrastructure; Male; Microscopy, Electron, Transmission/methods; Middle Aged; Mutagenesis, Site-Directed/physiology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Parkinson Disease/metabolism; Polymerase Chain Reaction/methods; Synucleins; Thiazoles/metabolism; Transfection/methods; Ubiquitin/metabolism; alpha-Synuclein; beta-Synuclein