Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.

Tondi, Donatella; Venturelli, Alberto; Ferrari, Stefania; Ghelli, Stefano; Costi, M Paola

Tondi, Donatella; Venturelli, Alberto; Ferrari, Stefania; Ghelli, Stefano; Costi, M Paola.

Affiliation

Tondi D; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, via Campi 183, 41100 Modena, Italy. tondid@unimore.it

J Med Chem ; 48(4): 913-6, 2005 Feb 24.

Article in En | MEDLINE | ID: mdl-15715461

Subject(s)

Bacteria/enzymology; Dansyl Compounds/chemistry; Thymidylate Synthase/antagonists & inhibitors; Thymidylate Synthase/chemistry; Tyrosine/analogs & derivatives; Tyrosine/chemistry; Dansyl Compounds/chemical synthesis; Humans; Lacticaseibacillus casei/enzymology; Models, Molecular; Molecular Conformation; Protein Binding; Structure-Activity Relationship; Substrate Specificity; Tyrosine/chemical synthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Thymidylate Synthase / Tyrosine / Bacteria / Dansyl Compounds Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Document type: Article Affiliation country: Italy Country of publication: United States

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