Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli.

Holtz, M S; Forman, S J; Bhatia, R

Holtz, M S; Forman, S J; Bhatia, R.

Affiliation

Holtz MS; Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.

Leukemia ; 19(6): 1034-41, 2005 Jun.

Article in En | MEDLINE | ID: mdl-15815728

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Hematopoietic Stem Cells/drug effects; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Piperazines/pharmacology; Pyrimidines/pharmacology; Adult; Aged; Antigens, CD34/metabolism; Apoptosis/physiology; Benzamides; Cell Division/drug effects; Cell Division/physiology; Female; Fusion Proteins, bcr-abl/antagonists & inhibitors; Fusion Proteins, bcr-abl/genetics; Gene Expression Regulation, Leukemic/drug effects; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/metabolism; Humans; Imatinib Mesylate; In Vitro Techniques; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology; Male; Middle Aged; Signal Transduction/drug effects; Signal Transduction/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyrimidines / Hematopoietic Stem Cells / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Apoptosis / Antineoplastic Agents Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2005 Document type: Article Affiliation country: United States Country of publication: United kingdom

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