Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer.

Thomas, Anne L; Morgan, Bruno; Horsfield, Mark A; Higginson, Anthony; Kay, Andrea; Lee, Lucy; Masson, Eric; Puccio-Pick, Marie; Laurent, Dirk; Steward, William P

Thomas, Anne L; Morgan, Bruno; Horsfield, Mark A; Higginson, Anthony; Kay, Andrea; Lee, Lucy; Masson, Eric; Puccio-Pick, Marie; Laurent, Dirk; Steward, William P.

Affiliation

Thomas AL; University of Leicester, United Kingdom. AT107@le.ac.uk

J Clin Oncol ; 23(18): 4162-71, 2005 Jun 20.

Article in En | MEDLINE | ID: mdl-15867205

Subject(s)

Angiogenesis Inhibitors/pharmacology; Angiogenesis Inhibitors/pharmacokinetics; Neoplasms/drug therapy; Phthalazines/pharmacology; Phthalazines/pharmacokinetics; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/pharmacokinetics; Pyridines/pharmacology; Pyridines/pharmacokinetics; Administration, Oral; Adult; Aged; Angiogenesis Inhibitors/administration & dosage; Area Under Curve; Chi-Square Distribution; Chromatography, High Pressure Liquid; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Phthalazines/administration & dosage; Protein Kinase Inhibitors/administration & dosage; Pyridines/administration & dosage; Statistics, Nonparametric; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Phthalazines / Pyridines / Angiogenesis Inhibitors / Protein Kinase Inhibitors / Neoplasms Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Clin Oncol Year: 2005 Document type: Article Affiliation country: United kingdom Country of publication: United States

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