Amifostine has an inhibitory effect on the radiation-induced p53-branched cascade in the immature mouse ovary.

Yoon, Yong-Dal; Kim, Ji Hyang; Lee, Kyoung Hee; Kim, Jin Kyu

Yoon, Yong-Dal; Kim, Ji Hyang; Lee, Kyoung Hee; Kim, Jin Kyu.

Affiliation

Yoon YD; Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Korea.

In Vivo ; 19(3): 509-14, 2005.

Article in En | MEDLINE | ID: mdl-15875769

Subject(s)

Amifostine/pharmacology; Ovary/radiation effects; Radiation-Protective Agents/pharmacology; Tumor Suppressor Protein p53/metabolism; Animals; Bromodeoxyuridine; Caspase 3; Caspases/metabolism; Caspases/radiation effects; Cell Division/drug effects; Dose-Response Relationship, Radiation; Female; Gamma Rays; Granulosa Cells/cytology; Granulosa Cells/drug effects; Granulosa Cells/radiation effects; Mice; Mice, Inbred ICR; Ovarian Follicle/cytology; Ovarian Follicle/drug effects; Ovary/cytology; Ovary/drug effects; Ovary/physiology; Poly(ADP-ribose) Polymerases/metabolism; Poly(ADP-ribose) Polymerases/radiation effects; Proto-Oncogene Proteins c-bcl-2/metabolism; Proto-Oncogene Proteins c-bcl-2/radiation effects; Sexual Maturation; Tumor Suppressor Protein p53/radiation effects; bcl-2-Associated X Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Ovary / Radiation-Protective Agents / Tumor Suppressor Protein p53 / Amifostine Limits: Animals Language: En Journal: In Vivo Journal subject: NEOPLASIAS Year: 2005 Document type: Article Country of publication: Greece

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