Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model.

Sprague, Jon E; Moze, Petra; Caden, David; Rusyniak, Daniel E; Holmes, Courtney; Goldstein, David S; Mills, Edward M

Sprague, Jon E; Moze, Petra; Caden, David; Rusyniak, Daniel E; Holmes, Courtney; Goldstein, David S; Mills, Edward M.

Affiliation

Sprague JE; Department of Pharmaceutical & Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, OH, USA.

Crit Care Med ; 33(6): 1311-6, 2005 Jun.

Article in En | MEDLINE | ID: mdl-15942349

Subject(s)

Adrenergic beta-Antagonists/therapeutic use; Carbazoles/therapeutic use; Fever/drug therapy; N-Methyl-3,4-methylenedioxyamphetamine/poisoning; Propanolamines/therapeutic use; Rhabdomyolysis/drug therapy; Analysis of Variance; Animals; Carvedilol; Catecholamines/blood; Fever/chemically induced; Fever/physiopathology; Male; Norepinephrine/blood; Random Allocation; Rats; Rats, Sprague-Dawley; Rhabdomyolysis/chemically induced; Rhabdomyolysis/physiopathology

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Collection: 01-internacional Database: MEDLINE Main subject: Propanolamines / Rhabdomyolysis / Carbazoles / N-Methyl-3,4-methylenedioxyamphetamine / Adrenergic beta-Antagonists / Fever Type of study: Evaluation_studies Limits: Animals Language: En Journal: Crit Care Med Year: 2005 Document type: Article Affiliation country: United States

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