Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478.

Jordan, Bénédicte F; Runquist, Matthew; Raghunand, Natarajan; Baker, Amanda; Williams, Ryan; Kirkpatrick, Lynn; Powis, Garth; Gillies, Robert J

Jordan, Bénédicte F; Runquist, Matthew; Raghunand, Natarajan; Baker, Amanda; Williams, Ryan; Kirkpatrick, Lynn; Powis, Garth; Gillies, Robert J.

Affiliation

Jordan BF; Department of Biochemistry, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA.

Neoplasia ; 7(5): 475-85, 2005 May.

Article in En | MEDLINE | ID: mdl-15967100

Subject(s)

Diffusion Magnetic Resonance Imaging/methods; Magnetic Resonance Imaging/methods; Mustard Compounds/pharmacology; Neoplasms/diagnosis; Neoplasms/pathology; Phenylpropionates/pharmacology; Transcription Factors/antagonists & inhibitors; Animals; Antibodies, Monoclonal/pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents/pharmacology; Bevacizumab; Cell Line, Tumor; Contrast Media/pharmacology; Female; Hemodynamics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Image Processing, Computer-Assisted; Immunohistochemistry; Mice; Mice, SCID; Necrosis; Neoplasm Transplantation; Permeability; Time Factors; Transcription Factors/metabolism; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylpropionates / Transcription Factors / Mustard Compounds / Magnetic Resonance Imaging / Diffusion Magnetic Resonance Imaging / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Neoplasia Journal subject: NEOPLASIAS Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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