Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug-drug interaction model rats.

Kanazu, Takushi; Okamura, Noboru; Yamaguchi, Yoshitaka; Baba, Takahiko; Koike, Masahiro

Kanazu, Takushi; Okamura, Noboru; Yamaguchi, Yoshitaka; Baba, Takahiko; Koike, Masahiro.

Affiliation

Kanazu T; Developmental Research Laboratories, Shionogi & Co., Ltd, 1-1, 3-chome, Futaba-cho, Toyonaka-shi, Osaka, Japan 561-0825. takushi.kanazu@shionogi.co.jp

Xenobiotica ; 35(4): 305-17, 2005 Apr.

Article in En | MEDLINE | ID: mdl-16019953

Subject(s)

Anti-Anxiety Agents/pharmacokinetics; Aryl Hydrocarbon Hydroxylases/metabolism; Midazolam/pharmacokinetics; Oxidoreductases, N-Demethylating/metabolism; Animals; Anti-Anxiety Agents/administration & dosage; Anti-Inflammatory Agents/administration & dosage; Anti-Inflammatory Agents/pharmacokinetics; Antifungal Agents/administration & dosage; Antifungal Agents/pharmacokinetics; Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors; Biotransformation/drug effects; Cytochrome P-450 CYP3A; Dexamethasone/administration & dosage; Dexamethasone/pharmacokinetics; Drug Interactions; Female; Intestinal Mucosa/metabolism; Ketoconazole/administration & dosage; Ketoconazole/pharmacokinetics; Liver/enzymology; Midazolam/administration & dosage; Oxidoreductases, N-Demethylating/antagonists & inhibitors; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases, N-Demethylating / Anti-Anxiety Agents / Midazolam / Aryl Hydrocarbon Hydroxylases Type of study: Prognostic_studies Limits: Animals Language: En Journal: Xenobiotica Year: 2005 Document type: Article Country of publication: United kingdom

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