Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme.

Joensuu, Heikki; Puputti, Marjut; Sihto, Harri; Tynninen, Olli; Nupponen, Nina N

Joensuu, Heikki; Puputti, Marjut; Sihto, Harri; Tynninen, Olli; Nupponen, Nina N.

Affiliation

Joensuu H; Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland. heikki.joensuu@hus.fi

J Pathol ; 207(2): 224-31, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16021678

Subject(s)

Brain Neoplasms/genetics; Glioblastoma/genetics; Protein-Tyrosine Kinases/antagonists & inhibitors; Proto-Oncogene Proteins c-kit/genetics; Receptor, Platelet-Derived Growth Factor alpha/genetics; Vascular Endothelial Growth Factor Receptor-2/genetics; Adult; Aged; Brain Neoplasms/pathology; Brain Neoplasms/secondary; Endothelial Cells/pathology; Exons/genetics; Female; Gene Amplification/genetics; Genes, erbB-1/genetics; Glioblastoma/pathology; Glioblastoma/secondary; Humans; Immunohistochemistry/methods; In Situ Hybridization, Fluorescence/methods; Male; Middle Aged; Mutation; Phosphorylation; Survival Analysis

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Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Protein-Tyrosine Kinases / Glioblastoma / Proto-Oncogene Proteins c-kit / Receptor, Platelet-Derived Growth Factor alpha / Vascular Endothelial Growth Factor Receptor-2 Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Pathol Year: 2005 Document type: Article Affiliation country: Finland Country of publication: United kingdom

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