Synthesis and biological activity of novel acridinylidene and benzylidene thiazolidinediones.

Mourão, R H; Silva, T G; Soares, A L M; Vieira, E S; Santos, J N; Lima, M C A; Lima, V L M; Galdino, S L; Barbe, J; Pitta, I R

Mourão, R H; Silva, T G; Soares, A L M; Vieira, E S; Santos, J N; Lima, M C A; Lima, V L M; Galdino, S L; Barbe, J; Pitta, I R.

Affiliation

Mourão RH; Departamento de Antibioticos, Universidade Federal de Pernambuco, Centro de Ciências Biológicas, 50670-901 Recife, Brasil.

Eur J Med Chem ; 40(11): 1129-33, 2005 Nov.

Article in En | MEDLINE | ID: mdl-16040159

ABSTRACT

A novel set of acridinylidene thiazolidinediones and benzylidene thiazolidinediones was synthesized by nucleophilic addition of cyanoacrylates. Some of these compounds were evaluated for their glucose lowering capability and their effects on the triglyceride level in alloxan diabetic mice.

Subject(s)

Acridines/chemical synthesis; Benzyl Compounds/chemical synthesis; Hypoglycemic Agents/chemical synthesis; Thiazolidinediones/chemical synthesis; Acridines/chemistry; Acridines/pharmacology; Animals; Benzyl Compounds/chemistry; Benzyl Compounds/pharmacology; Blood Glucose/drug effects; Body Weight/drug effects; Diabetes Mellitus, Experimental/blood; Diabetes Mellitus, Experimental/mortality; Drug Evaluation, Preclinical; Female; Hypoglycemic Agents/pharmacology; Male; Mice; Rosiglitazone; Thiazolidinediones/chemistry; Thiazolidinediones/pharmacology; Triglycerides/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Benzyl Compounds / Acridines / Thiazolidinediones / Hypoglycemic Agents Limits: Animals Language: En Journal: Eur J Med Chem Year: 2005 Document type: Article Affiliation country: Brazil Country of publication: France

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