A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway.

Mainardi, Jean-Luc; Fourgeaud, Martine; Hugonnet, Jean-Emmanuel; Dubost, Lionel; Brouard, Jean-Paul; Ouazzani, Jamal; Rice, Louis B; Gutmann, Laurent; Arthur, Michel

Mainardi, Jean-Luc; Fourgeaud, Martine; Hugonnet, Jean-Emmanuel; Dubost, Lionel; Brouard, Jean-Paul; Ouazzani, Jamal; Rice, Louis B; Gutmann, Laurent; Arthur, Michel.

Affiliation

Mainardi JL; INSERM, U655-Laboratoire de Recherche Moléculaire sur les Antibiotiques, Université Pierre et Marie Curie, Paris, France. jlmainar@bhdc.jussieu.fr

J Biol Chem ; 280(46): 38146-52, 2005 Nov 18.

Article in En | MEDLINE | ID: mdl-16144833

Subject(s)

Enterococcus faecium/enzymology; Peptidoglycan/chemistry; Alanine/chemistry; Amino Acid Sequence; Ampicillin/pharmacology; Animals; Anti-Bacterial Agents/pharmacology; Brain/microbiology; Catalysis; Cell Wall/metabolism; Chromatography; Chromatography, Ion Exchange; Cross-Linking Reagents/pharmacology; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Enterococcus faecium/metabolism; Escherichia coli/metabolism; Mass Spectrometry; Models, Biological; Models, Chemical; Models, Genetic; Molecular Sequence Data; Peptides/chemistry; Peptidyl Transferases/chemistry; Protein Binding; Substrate Specificity; beta-Lactams/chemistry; beta-Lactams/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Peptidoglycan / Enterococcus faecium Limits: Animals Language: En Journal: J Biol Chem Year: 2005 Document type: Article Affiliation country: France

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