Estrogen receptor alpha binds to peroxisome proliferator-activated receptor response element and negatively interferes with peroxisome proliferator-activated receptor gamma signaling in breast cancer cells.

Bonofiglio, Daniela; Gabriele, Sabrina; Aquila, Saveria; Catalano, Stefania; Gentile, Mariaelena; Middea, Emilia; Giordano, Francesca; Andò, Sebastiano

Bonofiglio, Daniela; Gabriele, Sabrina; Aquila, Saveria; Catalano, Stefania; Gentile, Mariaelena; Middea, Emilia; Giordano, Francesca; Andò, Sebastiano.

Affiliation

Bonofiglio D; Department of Pharmaco-Biology, University of Calabria, Cosenza, Italy.

Clin Cancer Res ; 11(17): 6139-47, 2005 Sep 01.

Article in En | MEDLINE | ID: mdl-16144913

Subject(s)

Breast Neoplasms/metabolism; Estrogen Receptor alpha/metabolism; PPAR gamma/metabolism; Response Elements/genetics; Signal Transduction; Breast Neoplasms/pathology; Cell Proliferation/drug effects; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Estradiol/pharmacology; HeLa Cells; Humans; Ligands; PPAR gamma/genetics; PTEN Phosphohydrolase; Phosphatidylinositol 3-Kinases/metabolism; Phosphoric Monoester Hydrolases/drug effects; Phosphoric Monoester Hydrolases/metabolism; Phosphorylation; Promoter Regions, Genetic/genetics; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Thiazolidinediones/pharmacology; Thymidine/metabolism; Transcription, Genetic; Transcriptional Activation; Tumor Suppressor Proteins/drug effects; Tumor Suppressor Proteins/metabolism; Vasodilator Agents/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Signal Transduction / Response Elements / PPAR gamma / Estrogen Receptor alpha Limits: Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2005 Document type: Article Affiliation country: Italy Country of publication: United States

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