Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles.

Zhang, Qinming; Williams, Eli S; Askin, Kristin F; Peng, Yuanlin; Bedford, Joel S; Liber, Howard L; Bailey, Susan M

Zhang, Qinming; Williams, Eli S; Askin, Kristin F; Peng, Yuanlin; Bedford, Joel S; Liber, Howard L; Bailey, Susan M.

Affiliation

Zhang Q; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

Radiat Res ; 164(4 Pt 2): 497-504, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16187756

Subject(s)

Cosmic Radiation/adverse effects; DNA-Binding Proteins/antagonists & inhibitors; Gamma Rays/adverse effects; Mutagenesis; Protein Serine-Threonine Kinases/antagonists & inhibitors; RNA Interference; Telomere/radiation effects; Cell Line; DNA-Activated Protein Kinase; DNA-Binding Proteins/physiology; Humans; Nuclear Proteins; Protein Serine-Threonine Kinases/physiology; Telomere/physiology

Key words

NASA Discipline Radiation Health; Non-NASA Center

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Collection: 01-internacional Database: MEDLINE Main subject: Mutagenesis / Telomere / Protein Serine-Threonine Kinases / Cosmic Radiation / RNA Interference / DNA-Binding Proteins / Gamma Rays Limits: Humans Language: En Journal: Radiat Res Year: 2005 Document type: Article Affiliation country: United States

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