RKTS-33, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity.

Mitsui, Tomokazu; Miyake, Yasunobu; Kakeya, Hideaki; Hayashi, Yujiro; Osada, Hiroyuki; Kataoka, Takao

Mitsui, Tomokazu; Miyake, Yasunobu; Kakeya, Hideaki; Hayashi, Yujiro; Osada, Hiroyuki; Kataoka, Takao.

Affiliation

Mitsui T; Center for Biological Resources and Informatics, Tokyo Institute of Technology, Yokohama, Japan.

Biosci Biotechnol Biochem ; 69(10): 1923-8, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16244443

Subject(s)

Apoptosis/drug effects; Cyclohexanones/pharmacology; Cytotoxicity, Immunologic/drug effects; Membrane Glycoproteins; T-Lymphocytes, Cytotoxic/immunology; Tumor Necrosis Factors; Animals; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Cell Line; Cyclohexanones/toxicity; Cytoplasmic Granules; DNA Fragmentation/drug effects; Epoxy Compounds; Exocytosis/drug effects; Fas Ligand Protein; Membrane Glycoproteins/analysis; Membrane Glycoproteins/drug effects; Membrane Glycoproteins/physiology; Mice; Perforin; Pore Forming Cytotoxic Proteins; Tumor Necrosis Factors/analysis; Tumor Necrosis Factors/physiology

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / T-Lymphocytes, Cytotoxic / Apoptosis / Cyclohexanones / Cytotoxicity, Immunologic / Tumor Necrosis Factors Limits: Animals Language: En Journal: Biosci Biotechnol Biochem Journal subject: BIOQUIMICA / BIOTECNOLOGIA Year: 2005 Document type: Article Affiliation country: Japan Country of publication: United kingdom

Search on Google

Add to My VHL

XML

PubMed Links