Liver targeting of hepatitis-B antiviral lamivudine using the HepDirect prodrug technology.

Reddy, K Raja; Colby, Timothy J; Fujitaki, James M; van Poelje, Paul D; Erion, Mark D

Reddy, K Raja; Colby, Timothy J; Fujitaki, James M; van Poelje, Paul D; Erion, Mark D.

Affiliation

Reddy KR; Department of Chemistry, Metabasis Therapeutics, Inc., 9390 Towne Centre Drive, Building 300, San Diego, CA 92121, USA.

Nucleosides Nucleotides Nucleic Acids ; 24(5-7): 375-81, 2005.

Article in En | MEDLINE | ID: mdl-16247954

Subject(s)

Antiviral Agents/pharmacology; Hepatitis B/drug therapy; Lamivudine/pharmacology; Liver/drug effects; Liver/virology; Prodrugs/pharmacology; Animals; Area Under Curve; Cells, Cultured; Hepatocytes/drug effects; Humans; Kinetics; Microsomes, Liver/drug effects; Models, Chemical; Phosphates/chemistry; Phosphorylation; Rats; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Prodrugs / Lamivudine / Hepatitis B / Liver Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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