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Kumada coupling of aryl and vinyl tosylates under mild conditions.
Limmert, Michael E; Roy, Amy H; Hartwig, John F.
Affiliation
  • Limmert ME; Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107, USA.
J Org Chem ; 70(23): 9364-70, 2005 Nov 11.
Article in En | MEDLINE | ID: mdl-16268609
[Reaction: see text]. Aryl and alkenyl tosylates are easily prepared, inexpensive and, thus, attractive for transition-metal-catalyzed couplings, but their reactivity is low. We report examples of mild, palladium-catalyzed coupling of aryl, alkenyl, and alkyl Grignard reagents with aryl and alkenyl tosylates. The resulting biaryls, vinylarenes, and alkylarenes were isolated in good to excellent yield. These couplings were conducted with a nearly equimolar ratio of the two reactants, and many examples were conducted at room temperature.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Palladium / Tosyl Compounds Language: En Journal: J Org Chem Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Palladium / Tosyl Compounds Language: En Journal: J Org Chem Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States