Substrate-induced conformational changes in Bacillus subtilis glutamate racemase and their implications for drug discovery.

Ruzheinikov, Sergey N; Taal, Makie A; Sedelnikova, Svetlana E; Baker, Patrick J; Rice, David W

Ruzheinikov, Sergey N; Taal, Makie A; Sedelnikova, Svetlana E; Baker, Patrick J; Rice, David W.

Affiliation

Ruzheinikov SN; Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom.

Structure ; 13(11): 1707-13, 2005 Nov.

Article in En | MEDLINE | ID: mdl-16271894

Subject(s)

Amino Acid Isomerases/chemistry; Amino Acid Isomerases/metabolism; Bacillus subtilis/enzymology; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Drug Design; Amino Acid Isomerases/antagonists & inhibitors; Amino Acid Sequence; Bacterial Proteins/antagonists & inhibitors; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Molecular Sequence Data; Protein Binding; Protein Conformation; Sequence Alignment; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Bacillus subtilis / Bacterial Proteins / Drug Design / Amino Acid Isomerases Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2005 Document type: Article Affiliation country: United kingdom Country of publication: United States

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