Thrombomodulin tightens the thrombin active site loops to promote protein C activation.

Koeppe, Julia R; Seitova, Almagoul; Mather, Timothy; Komives, Elizabeth A

Koeppe, Julia R; Seitova, Almagoul; Mather, Timothy; Komives, Elizabeth A.

Affiliation

Koeppe JR; Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093-0378, USA.

Biochemistry ; 44(45): 14784-91, 2005 Nov 15.

Article in En | MEDLINE | ID: mdl-16274226

Subject(s)

Protein C/metabolism; Thrombin/chemistry; Thrombomodulin/chemistry; Amides/chemistry; Amino Acid Sequence; Animals; Binding Sites; Cattle; Deuterium Exchange Measurement; Enzyme Activation; Epidermal Growth Factor/chemistry; Humans; Molecular Sequence Data; Protein C/chemistry; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment; Thrombin/metabolism; Thrombomodulin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Protein C / Thrombin / Thrombomodulin Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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