Inhibition of AIF-1 expression by constitutive siRNA expression reduces macrophage migration, proliferation, and signal transduction initiated by atherogenic stimuli.

Tian, Ying; Kelemen, Sheri E; Autieri, Michael V

Tian, Ying; Kelemen, Sheri E; Autieri, Michael V.

Affiliation

Tian Y; Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Rm. 810, MRB, 3420 N. Broad St., Philadelphia, PA 19140, USA.

Am J Physiol Cell Physiol ; 290(4): C1083-91, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16291819

Subject(s)

Atherosclerosis; Cell Movement/physiology; Cell Proliferation; DNA-Binding Proteins/metabolism; Macrophages/metabolism; RNA, Small Interfering/metabolism; Signal Transduction/physiology; Animals; Antigens, CD/metabolism; Antigens, Differentiation, Myelomonocytic/metabolism; Calcium-Binding Proteins; Coronary Vessels/cytology; Coronary Vessels/metabolism; Coronary Vessels/pathology; Culture Media, Conditioned/chemistry; DNA-Binding Proteins/genetics; Humans; Lipoproteins, LDL/pharmacology; Macrophage Activation; Macrophages/cytology; Macrophages/drug effects; Mice; Microfilament Proteins; Mitogen-Activated Protein Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; RNA, Small Interfering/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cell Movement / RNA, Small Interfering / Cell Proliferation / DNA-Binding Proteins / Atherosclerosis / Macrophages Limits: Animals / Humans Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2006 Document type: Article Affiliation country: United States

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