Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis.

Kahlenberg, J Michelle; Lundberg, Kathleen C; Kertesy, Sylvia B; Qu, Yan; Dubyak, George R

Kahlenberg, J Michelle; Lundberg, Kathleen C; Kertesy, Sylvia B; Qu, Yan; Dubyak, George R.

Affiliation

Kahlenberg JM; Department of Pathology, Case School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.

J Immunol ; 175(11): 7611-22, 2005 Dec 01.

Article in En | MEDLINE | ID: mdl-16301671

Subject(s)

Caspase 1/metabolism; Macrophages/immunology; NF-kappa B/metabolism; Receptors, Purinergic P2/metabolism; Toll-Like Receptors/metabolism; Animals; Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation/immunology; Enzyme-Linked Immunosorbent Assay; I-kappa B Kinase/immunology; I-kappa B Kinase/metabolism; Interleukin-1/immunology; Interleukin-1/metabolism; Lipopolysaccharides/immunology; MAP Kinase Kinase 4/immunology; MAP Kinase Kinase 4/metabolism; Macrophage Activation/immunology; Macrophages/metabolism; Mice; NF-kappa B/immunology; Receptors, Purinergic P2/immunology; Receptors, Purinergic P2X7; Signal Transduction/immunology; Toll-Like Receptors/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Receptors, Purinergic P2 / Caspase 1 / Toll-Like Receptors / Macrophages Limits: Animals Language: En Journal: J Immunol Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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