Structure-activity relationship of an alpha-toxin Bs-Tx28 from scorpion (Buthus sindicus) venom suggests a new alpha-toxin subfamily.

Ali, Syed Abid; Wang, Bingxian; Alam, Mehtab; Beck, Alexander; Stoeva, Stanka; Voelter, Wolfgang; Abbasi, Atiya; Duszenko, Michael

Ali, Syed Abid; Wang, Bingxian; Alam, Mehtab; Beck, Alexander; Stoeva, Stanka; Voelter, Wolfgang; Abbasi, Atiya; Duszenko, Michael.

Affiliation

Ali SA; International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan. syedabid_ali@yahoo.com

Arch Biochem Biophys ; 445(1): 81-94, 2006 Jan 01.

Article in En | MEDLINE | ID: mdl-16309623

Subject(s)

Neurotoxins/chemistry; Scorpion Venoms/chemistry; Action Potentials; Amino Acid Sequence; Animals; Blattellidae; Circular Dichroism; Gastrointestinal Motility; In Vitro Techniques; Jejunum/drug effects; Jejunum/innervation; Jejunum/physiology; Lethal Dose 50; Mesenteric Arteries/innervation; Mice; Models, Molecular; Molecular Sequence Data; Neurotoxins/toxicity; Phylogeny; Protein Conformation; Rats; Rats, Sprague-Dawley; Scorpion Venoms/toxicity; Sequence Alignment; Sequence Homology, Amino Acid; Sodium Channel Blockers/chemistry; Sodium Channel Blockers/toxicity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Tetrodotoxin/chemistry; Tetrodotoxin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Scorpion Venoms / Neurotoxins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Arch Biochem Biophys Year: 2006 Document type: Article Affiliation country: Pakistan Country of publication: United States

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