Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.

Yue, Xu; Lu, Melissa; Lancaster, Techie; Cao, Phillip; Honda, Shin-Ichiro; Staufenbiel, Matthias; Harada, Nobuhiro; Zhong, Zhenyu; Shen, Yong; Li, Rena

Yue, Xu; Lu, Melissa; Lancaster, Techie; Cao, Phillip; Honda, Shin-Ichiro; Staufenbiel, Matthias; Harada, Nobuhiro; Zhong, Zhenyu; Shen, Yong; Li, Rena.

Affiliation

Yue X; L. J. Roberts Center for Alzheimer's Research and Haldeman Laboratory for Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ 85351, USA.

Proc Natl Acad Sci U S A ; 102(52): 19198-203, 2005 Dec 27.

Article in En | MEDLINE | ID: mdl-16365303

Subject(s)

Amyloid beta-Peptides/physiology; Brain/metabolism; Estrogens/deficiency; Amyloid Precursor Protein Secretases; Amyloid beta-Peptides/metabolism; Animals; Aspartic Acid Endopeptidases; Blotting, Western; Brain/pathology; Disease Models, Animal; Endopeptidases/metabolism; Enzyme-Linked Immunosorbent Assay; Estradiol/metabolism; Estrogens/blood; Estrogens/metabolism; Female; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neurons/pathology; Phagocytosis; Radioimmunoassay; Risk Factors; Sex Factors; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Amyloid beta-Peptides / Estrogens Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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