Spirocyclopropyl pyrrolidines as a new series of alpha-L-fucosidase inhibitors.

Laroche, Christophe; Behr, Jean-Bernard; Szymoniak, Jan; Bertus, Philippe; Schütz, Catherine; Vogel, Pierre; Plantier-Royon, Richard

Laroche, Christophe; Behr, Jean-Bernard; Szymoniak, Jan; Bertus, Philippe; Schütz, Catherine; Vogel, Pierre; Plantier-Royon, Richard.

Affiliation

Laroche C; Laboratoire Réactions Sélectives et Applications, Université de Reims Champagne-Ardenne, UMR URCA/CNRS 6519, UFR Sciences, BP 1039, F-51687 Reims Cedex 2, France.

Bioorg Med Chem ; 14(12): 4047-54, 2006 Jun 15.

Article in En | MEDLINE | ID: mdl-16488612

Subject(s)

Enzyme Inhibitors/pharmacology; Pyrrolidines/pharmacology; Spiro Compounds/chemistry; alpha-L-Fucosidase/antagonists & inhibitors; Animals; Cattle; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Kidney/enzymology; Molecular Conformation; Pyrrolidines/chemical synthesis; Pyrrolidines/chemistry; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Spiro Compounds / Enzyme Inhibitors / Alpha-L-Fucosidase Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: France Country of publication: United kingdom

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