Tumour overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126.

Cullis, Elizabeth R; Kalber, Tammy L; Ashton, Susan E; Cartwright, Judith E; Griffiths, John R; Ryan, Anderson J; Robinson, Simon P

Cullis, Elizabeth R; Kalber, Tammy L; Ashton, Susan E; Cartwright, Judith E; Griffiths, John R; Ryan, Anderson J; Robinson, Simon P.

Affiliation

Cullis ER; Division of Basic Medical Sciences, St. George's, University of London, Cranmer Terrace, London SW17 ORE, UK.

Microvasc Res ; 71(2): 76-84, 2006 Mar.

Article in En | MEDLINE | ID: mdl-16530791

Subject(s)

Antineoplastic Agents/pharmacology; Neovascularization, Pathologic/enzymology; Neovascularization, Pathologic/metabolism; Nitric Oxide Synthase Type II/metabolism; Organophosphorus Compounds/pharmacology; Adenocarcinoma/blood supply; Adenocarcinoma/metabolism; Adenocarcinoma/pathology; Animals; Cell Culture Techniques; Cell Line, Tumor; Colonic Neoplasms/blood supply; Colonic Neoplasms/metabolism; Colonic Neoplasms/pathology; Dose-Response Relationship, Drug; Drug Resistance; Humans; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Mice, Nude; Neoplasm Transplantation; Time Factors; Transplantation, Heterologous

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Collection: 01-internacional Database: MEDLINE Main subject: Organophosphorus Compounds / Nitric Oxide Synthase Type II / Neovascularization, Pathologic / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Microvasc Res Year: 2006 Document type: Article Affiliation country: United kingdom Country of publication: United States

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