Effect of mexiletine on vincristine-induced painful neuropathy in mice.

Kamei, Junzo; Nozaki, Chihiro; Saitoh, Akiyoshi

Kamei, Junzo; Nozaki, Chihiro; Saitoh, Akiyoshi.

Affiliation

Kamei J; Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan. kamei@hoshi.ac.jp

Eur J Pharmacol ; 536(1-2): 123-7, 2006 Apr 24.

Article in En | MEDLINE | ID: mdl-16556439

Subject(s)

Mexiletine/pharmacology; Neuralgia/prevention & control; Vincristine/toxicity; Animals; Arginine/administration & dosage; Arginine/pharmacology; Behavior, Animal/drug effects; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/toxicity; Hyperalgesia/chemically induced; Hyperalgesia/prevention & control; Injections, Intraperitoneal; Injections, Spinal; Male; Mexiletine/administration & dosage; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester/administration & dosage; NG-Nitroarginine Methyl Ester/toxicity; Neuralgia/chemically induced; Nitric Oxide Synthase/antagonists & inhibitors; Nitric Oxide Synthase/metabolism; Nitriles/administration & dosage; Nitriles/toxicity; Pain Measurement/methods; Pyrethrins/administration & dosage; Pyrethrins/toxicity; Vincristine/administration & dosage

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Collection: 01-internacional Database: MEDLINE Main subject: Vincristine / Mexiletine / Neuralgia Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2006 Document type: Article Affiliation country: Japan Country of publication: Netherlands

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