Bioconversion of deoxypodophyllotoxin into epipodophyllotoxin in E. coli using human cytochrome P450 3A4.

Vasilev, Nikolay P; Julsing, Mattijs K; Koulman, Albert; Clarkson, Cailean; Woerdenbag, Herman J; Ionkova, Iliana; Bos, Rein; Jaroszewski, Jerzy W; Kayser, Oliver; Quax, Wim J

Vasilev, Nikolay P; Julsing, Mattijs K; Koulman, Albert; Clarkson, Cailean; Woerdenbag, Herman J; Ionkova, Iliana; Bos, Rein; Jaroszewski, Jerzy W; Kayser, Oliver; Quax, Wim J.

Affiliation

Vasilev NP; Department of Pharmaceutical Biology, University of Groningen, Groningen Research Institute of Pharmacy (GRIP), Antonius Deusinglaan 1, NL-9713 AV Groningen, The Netherlands.

J Biotechnol ; 126(3): 383-93, 2006 Nov 10.

Article in En | MEDLINE | ID: mdl-16753237

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Escherichia coli/metabolism; Podophyllotoxin/analogs & derivatives; Podophyllotoxin/metabolism; Protein Engineering/methods; Biotransformation; Cytochrome P-450 Enzyme System/genetics; Drugs, Chinese Herbal; Escherichia coli/genetics; Genetic Enhancement/methods; Humans; Recombinant Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Podophyllotoxin / Protein Engineering / Cytochrome P-450 Enzyme System / Escherichia coli Limits: Humans Language: En Journal: J Biotechnol Journal subject: BIOTECNOLOGIA Year: 2006 Document type: Article Affiliation country: Netherlands Country of publication: Netherlands

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