Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.

Kusama, Toshiyuki; Mukai, Mutsuko; Tatsuta, Masaharu; Nakamura, Hiroyuki; Inoue, Masahiro

Kusama, Toshiyuki; Mukai, Mutsuko; Tatsuta, Masaharu; Nakamura, Hiroyuki; Inoue, Masahiro.

Affiliation

Kusama T; Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan. kusama-to@ mc.pref.osaka.jp

Int J Oncol ; 29(1): 217-23, 2006 Jul.

Article in En | MEDLINE | ID: mdl-16773203

Subject(s)

Breast Neoplasms/enzymology; Cell Adhesion/drug effects; Cell Movement/drug effects; Protein Processing, Post-Translational; rho GTP-Binding Proteins/metabolism; rhoA GTP-Binding Protein/metabolism; Alkyl and Aryl Transferases/antagonists & inhibitors; Alkyl and Aryl Transferases/metabolism; Animals; Benzamides/pharmacology; Breast Neoplasms/pathology; Cattle; Cell Line, Tumor; Cell Shape/drug effects; Coculture Techniques; Collagen; Drug Combinations; Endothelial Cells/physiology; Farnesyltranstransferase/antagonists & inhibitors; Farnesyltranstransferase/metabolism; Fatty Acids, Monounsaturated/pharmacology; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Indoles/pharmacology; Laminin; Methionine/analogs & derivatives; Methionine/pharmacology; Neoplasm Invasiveness; Protein Prenylation; Protein Processing, Post-Translational/drug effects; Protein Transport/drug effects; Proteoglycans; rhoC GTP-Binding Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Cell Adhesion / Cell Movement / Protein Processing, Post-Translational / Rho GTP-Binding Proteins / RhoA GTP-Binding Protein Limits: Animals / Female / Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2006 Document type: Article Country of publication: Greece

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