Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy.

Sabharwal, Ami; Middleton, Mark R

Sabharwal, Ami; Middleton, Mark R.

Affiliation

Sabharwal A; Cancer Research UK, Medical Oncology Unit, Churchill Hospital, Oxford OX3 7LJ, UK.

Curr Opin Pharmacol ; 6(4): 355-63, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16777483

Subject(s)

Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Gene Expression Regulation, Neoplastic/drug effects; Neoplasms/drug therapy; O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors; Animals; Antineoplastic Agents/administration & dosage; Camptothecin/analogs & derivatives; Camptothecin/pharmacology; Camptothecin/therapeutic use; Clinical Trials as Topic; DNA Adducts/drug effects; DNA Methylation/drug effects; DNA Topoisomerases, Type I/metabolism; Dacarbazine/analogs & derivatives; Dacarbazine/pharmacology; Dacarbazine/therapeutic use; Drug Administration Schedule; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Guanine/analogs & derivatives; Guanine/pharmacology; Guanine/therapeutic use; Humans; Irinotecan; Neoplasms/enzymology; Neoplasms/genetics; O(6)-Methylguanine-DNA Methyltransferase/genetics; O(6)-Methylguanine-DNA Methyltransferase/metabolism; Organoplatinum Compounds/pharmacology; Organoplatinum Compounds/therapeutic use; Prognosis; Promoter Regions, Genetic/drug effects; Temozolomide; Topoisomerase I Inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / O(6)-Methylguanine-DNA Methyltransferase / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Curr Opin Pharmacol Journal subject: FARMACOLOGIA Year: 2006 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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