Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

Syvänen, Stina; Blomquist, Gunnar; Sprycha, Margareta; Höglund, A Urban; Roman, Magnus; Eriksson, Olof; Hammarlund-Udenaes, Margareta; Långström, Bengt; Bergström, Mats

Syvänen, Stina; Blomquist, Gunnar; Sprycha, Margareta; Höglund, A Urban; Roman, Magnus; Eriksson, Olof; Hammarlund-Udenaes, Margareta; Långström, Bengt; Bergström, Mats.

Affiliation

Syvänen S; Uppsala Imanet, PO Box 967, SE-751 85 Uppsala, Sweden. Stina.Syvanen@uppsala.imanet.se

Neuroimage ; 32(3): 1134-41, 2006 Sep.

Article in En | MEDLINE | ID: mdl-16857389

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; Blood-Brain Barrier/drug effects; Brain/diagnostic imaging; Cyclosporine/pharmacology; Immunosuppressive Agents/pharmacology; Algorithms; Animals; Biotransformation; Calcium Channel Blockers/administration & dosage; Calcium Channel Blockers/pharmacokinetics; Carbon Radioisotopes; Cyclosporine/blood; Immunosuppressive Agents/blood; Isotope Labeling; Male; Models, Statistical; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Verapamil/administration & dosage; Verapamil/pharmacokinetics

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Brain / Blood-Brain Barrier / Cyclosporine / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Immunosuppressive Agents Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Neuroimage Journal subject: DIAGNOSTICO POR IMAGEM Year: 2006 Document type: Article Affiliation country: Sweden Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links