The missense genetic polymorphisms of human CYP2A13: functional significance in carcinogen activation and identification of a null allelic variant.

Wang, Shou-Lin; He, Xiao-Yang; Shen, Jian; Wang, Jia-Sheng; Hong, Jun-Yan

Wang, Shou-Lin; He, Xiao-Yang; Shen, Jian; Wang, Jia-Sheng; Hong, Jun-Yan.

Affiliation

Wang SL; School of Public Health/Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA.

Toxicol Sci ; 94(1): 38-45, 2006 Nov.

Article in En | MEDLINE | ID: mdl-16917071

Subject(s)

Aryl Hydrocarbon Hydroxylases/genetics; Mutation, Missense; Polymorphism, Genetic/genetics; Aflatoxin B1/metabolism; Aflatoxin B1/toxicity; Alleles; Animals; Aryl Hydrocarbon Hydroxylases/metabolism; CHO Cells; Carcinogens/metabolism; Carcinogens/toxicity; Cell Line; Cell Survival/drug effects; Cricetinae; Cricetulus; DNA Nucleotidyltransferases/genetics; DNA Nucleotidyltransferases/metabolism; Gene Expression Regulation, Enzymologic; Genetic Variation; Humans; Immunoblotting; Isoenzymes/genetics; Isoenzymes/metabolism; Microsomes/drug effects; Microsomes/metabolism; Nitrosamines/metabolism; Nitrosamines/toxicity; Spodoptera; Time Factors; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Aryl Hydrocarbon Hydroxylases / Mutation, Missense Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2006 Document type: Article Affiliation country: United States

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