Potential effect on cellular response to cadmium of a single-nucleotide A --> G polymorphism in the promoter of the human gene for metallothionein IIA.

Kita, Kayoko; Miura, Nobuhiko; Yoshida, Minoru; Yamazaki, Kentaro; Ohkubo, Takayoshi; Imai, Yutaka; Naganuma, Akira

Kita, Kayoko; Miura, Nobuhiko; Yoshida, Minoru; Yamazaki, Kentaro; Ohkubo, Takayoshi; Imai, Yutaka; Naganuma, Akira.

Affiliation

Kita K; Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Hum Genet ; 120(4): 553-60, 2006 Nov.

Article in En | MEDLINE | ID: mdl-16927099

Subject(s)

Cadmium Chloride/pharmacology; Metallothionein/genetics; Polymorphism, Single Nucleotide; Adult; Base Sequence; Cell Line; Chlorides/pharmacology; DNA/chemistry; DNA/genetics; DNA Mutational Analysis; Dioxins/pharmacology; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Gene Expression Regulation/drug effects; Gene Frequency; Genotype; Humans; Luciferases/genetics; Luciferases/metabolism; Metallothionein/metabolism; Oligonucleotides/genetics; Oligonucleotides/metabolism; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Protein Binding/drug effects; TATA Box; Transfection; Zinc Compounds/pharmacology

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Cadmium Chloride / Polymorphism, Single Nucleotide / Metallothionein Limits: Adult / Humans Language: En Journal: Hum Genet Year: 2006 Document type: Article Affiliation country: Japan Country of publication: Germany

Search on Google

Add to My VHL

XML

PubMed Links