Improved pharmacological properties for superoxide dismutase modified with beta-cyclodextrin-carboxymethylcellulose polymer.

Valdivia, Aymara; Pérez, Yunel; Ramírez, Hector; Cao, Roberto; Villalonga, Reynaldo

Valdivia, Aymara; Pérez, Yunel; Ramírez, Hector; Cao, Roberto; Villalonga, Reynaldo.

Affiliation

Valdivia A; Center for Enzyme Technology, University of Matanzas, Autopista a Varadero Km. 3.5, Matanzas, C.P. 44740, Cuba.

Biotechnol Lett ; 28(18): 1465-70, 2006 Sep.

Article in En | MEDLINE | ID: mdl-16955352

ABSTRACT

Superoxide dismutase was glycosidated with cyclodextrin-branched carboxymethylcellulose. The modified enzyme contained 1.4 mol polymer per mol protein and retained 87% of the initial activity. The anti-inflammatory activity of superoxide dismutase was 2.2-times increased after conjugation and its plasma half-life time was prolonged from 4.8 min to 7.2 h.

Subject(s)

Anti-Inflammatory Agents/pharmacokinetics; Carboxymethylcellulose Sodium/analogs & derivatives; Cyclodextrins/pharmacokinetics; Superoxide Dismutase/pharmacokinetics; Animals; Carboxymethylcellulose Sodium/chemical synthesis; Carboxymethylcellulose Sodium/chemistry; Carboxymethylcellulose Sodium/pharmacokinetics; Carrageenan; Cyclodextrins/chemical synthesis; Edema/chemically induced; Edema/drug therapy; Foot; Male; Rats; Rats, Wistar; beta-Cyclodextrins/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Carboxymethylcellulose Sodium / Cyclodextrins / Anti-Inflammatory Agents Limits: Animals Language: En Journal: Biotechnol Lett Year: 2006 Document type: Article Affiliation country: Cuba Country of publication: Netherlands

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