Ginsenoside-Rd from panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells.

Guan, Yong-Yuan; Zhou, Jia-Guo; Zhang, Zheng; Wang, Guan-Lei; Cai, Bing-Xiang; Hong, Liang; Qiu, Qin-Ying; He, Hua

Guan, Yong-Yuan; Zhou, Jia-Guo; Zhang, Zheng; Wang, Guan-Lei; Cai, Bing-Xiang; Hong, Liang; Qiu, Qin-Ying; He, Hua.

Affiliation

Guan YY; Department of Pharmacology, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou, PR China. guanyy@mail.sysu.edu.cn

Eur J Pharmacol ; 548(1-3): 129-36, 2006 Oct 24.

Article in En | MEDLINE | ID: mdl-16973156

Subject(s)

Calcium Channel Blockers/pharmacology; Calcium Channels/drug effects; Calcium/metabolism; Ginsenosides/pharmacology; Muscle, Smooth, Vascular/drug effects; Animals; Aorta, Thoracic/drug effects; Aorta, Thoracic/physiology; Calcium Channels/physiology; Cell Line; Cell Membrane/drug effects; Cell Membrane/metabolism; In Vitro Techniques; Microsomes/drug effects; Microsomes/metabolism; Muscle Contraction/drug effects; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/physiology; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/physiology; Panax notoginseng/chemistry; Phenylephrine/pharmacology; Rabbits; Rats; Rats, Wistar; Thapsigargin/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channel Blockers / Calcium Channels / Calcium / Ginsenosides / Muscle, Smooth, Vascular Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2006 Document type: Article Country of publication: Netherlands

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