Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope.

Yoshida, Hirotaka; Goedert, Michel

Yoshida, Hirotaka; Goedert, Michel.

Affiliation

Yoshida H; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. hiro@mrc-lmb.cam.ac.uk

J Neurochem ; 99(1): 154-64, 2006 Oct.

Article in En | MEDLINE | ID: mdl-16987243

Subject(s)

Cyclic AMP-Dependent Protein Kinases/metabolism; Heparin/pharmacology; Mitogen-Activated Protein Kinase 13/metabolism; Mitogen-Activated Protein Kinase 9/metabolism; tau Proteins/metabolism; Amino Acid Sequence; Animals; Enzyme Activation; Kinetics; Mice; Microtubules/physiology; Peptide Fragments/chemistry; Peptide Fragments/metabolism; Phosphorylation

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Collection: 01-internacional Database: MEDLINE Main subject: Heparin / Tau Proteins / Cyclic AMP-Dependent Protein Kinases / Mitogen-Activated Protein Kinase 9 / Mitogen-Activated Protein Kinase 13 Limits: Animals Language: En Journal: J Neurochem Year: 2006 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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