Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events.

Mitchell, Jane A; Lucas, Ruth; Vojnovic, Ivana; Hasan, Kamrul; Pepper, John R; Warner, Timothy D

Mitchell, Jane A; Lucas, Ruth; Vojnovic, Ivana; Hasan, Kamrul; Pepper, John R; Warner, Timothy D.

Affiliation

Mitchell JA; Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Royal Brompton Hospital, Imperial College School of Medicine, London, UK.

FASEB J ; 20(14): 2468-75, 2006 Dec.

Article in En | MEDLINE | ID: mdl-17142796

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Blood Platelets/drug effects; Cyclooxygenase 1/metabolism; Endothelial Cells/drug effects; Thrombosis/chemically induced; Aorta/cytology; Blood Platelets/enzymology; Cyclooxygenase 2/metabolism; Cyclooxygenase Inhibitors/pharmacology; Endothelial Cells/enzymology; Epoprostenol/metabolism; Gene Expression Regulation, Enzymologic; Humans; Thromboxane A2/metabolism; Veins/cytology; Veins/drug effects; Veins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Blood Platelets / Anti-Inflammatory Agents, Non-Steroidal / Endothelial Cells / Cyclooxygenase 1 Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2006 Document type: Article Affiliation country: United kingdom Country of publication: United States

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