A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission.

Tumpey, Terrence M; Maines, Taronna R; Van Hoeven, Neal; Glaser, Laurel; Solórzano, Alicia; Pappas, Claudia; Cox, Nancy J; Swayne, David E; Palese, Peter; Katz, Jacqueline M; García-Sastre, Adolfo

Tumpey, Terrence M; Maines, Taronna R; Van Hoeven, Neal; Glaser, Laurel; Solórzano, Alicia; Pappas, Claudia; Cox, Nancy J; Swayne, David E; Palese, Peter; Katz, Jacqueline M; García-Sastre, Adolfo.

Affiliation

Tumpey TM; Influenza Branch, Mailstop G-16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. tft9@cdc.gov

Science ; 315(5812): 655-9, 2007 Feb 02.

Article in En | MEDLINE | ID: mdl-17272724

Subject(s)

Amino Acid Substitution; Hemagglutinin Glycoproteins, Influenza Virus/genetics; Influenza A Virus, H1N1 Subtype/genetics; Influenza, Human/transmission; Influenza, Human/virology; Mutation; Animals; Cell Line; Disease Models, Animal; Dogs; Ferrets; Galactose/metabolism; Glycoconjugates/metabolism; Hemagglutinin Glycoproteins, Influenza Virus/metabolism; Humans; Influenza A Virus, H1N1 Subtype/pathogenicity; Influenza A Virus, H1N1 Subtype/physiology; Influenza, Human/pathology; Lung/pathology; Lung/virology; Male; Nose/virology; Receptors, Virus/metabolism; Respiratory System/virology; Sialic Acids/metabolism; Virulence; Virus Replication; Virus Shedding

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Collection: 01-internacional Database: MEDLINE Main subject: Hemagglutinin Glycoproteins, Influenza Virus / Amino Acid Substitution / Influenza, Human / Influenza A Virus, H1N1 Subtype / Mutation Limits: Animals / Humans / Male Language: En Journal: Science Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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